Rhea replaced Valerie Harper, and appeared alongside Marilu Henner in the production of The Tale of the Allergist's Wife, at the New York Barrymore Theatre in June of 2006.
Rhea was directed by DeVito in a segment of Steven Spielberg's NBC series Amazing Stories, called The Wedding Ring.
Rhea acted alongside rappers Kid 'N' Play in the 1992 comedy Class Act.
Rhea starred in several television dramas that dealt with social issues that she is concerned with in real life, involving children and their well being. Some of the movies are: I Want To Keep My Baby, Having Babies II, and Like Normal People.
Rhea played the role of 'Honey' in the Michael Moore film Canadian Bacon.
Rhea was nominated ten out of eleven possible times for an Emmy Award for her work on Cheers for 'Best Supporting Actress in a Comedy Series'. The only year that she was not nominated was in 1992.
Rhea started to appear in drama-themed movies on television in the late 1970s, starting with the CBS drama Mary Jane Harper Cried Last Night and ABC's Intimate Strangers, both aired in 1977.
Rhea first gained attention from her occasional appearances on boyfriend Danny DeVito's hit sitcom, Taxi. She played his girlfriend, Zena.
Rhea was landing bit parts in several off-Broadway productions, but her personal life was majorly affected while in the audience at one of the plays she went to. She went to see a friend perform in The Shrinking Bride, and was drawn to one of the cast members. After the show, she was introduced to her future husband, Danny Devito.
Along with George Wendt and Ted Danson, Rhea Perlman was is one of three actors that appear in all episodes of Cheers.
In 1996, she starred in a movie with husband, Danny Devito. The movie was called Matilda and Danny Devito was also the director of the movie.
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