She attended Germantown High School.
Missi married Antonio Sacre in May 2000. The couple divorced in 2005.
Missi has a three-legged dog named Saskia, and a cat named Chester.
When Missi was a baby her family started calling her 'our little missy', the name stuck and she started using the name 'Missi' instead of her real name.
She attended the North Carolina School of the Arts in Winston-Salem, NC. There she earned a degree in acting.