Lee Patrick was a popular presence in New York during the 1920s and early 1930s. She received such scene-stealing roles as "June Moon," "Little Women," "Blessed Event" and "Stage Door."
Lee Patrick's only staring television role was in "Topper" as Henrietta Topper. All her other roles in television were guest roles.
Lee Patrick has been quoted as saying that she has "played them all: big sister, society matron, hooker, wisecracker, bubble dancer, nuthouse inmate, and even a song and dance girl."
Lee Patrick’s success in Stage Door in 1937 led Hollywood to reprise her role in the film version. The part was rewritten and split from a single character into two characters. The roles went to Katharine Hepburn and Ginger Rogers.
In 1975 she made her final film. She attempted to reprise her role as Effie Perine in the story titled “The Black Bird”. It was reworking of the Sam Spade story. The title role went to George Segal as Sam Spade Junior. The story is about a man forced to continue his father's work, and to keep his increasingly sarcastic secretary. The film attempted to turn its revered predecessor into a comedy, and was a box office failure.
Lee Patrick was happily married to new paper writer Tom Wood from 1937 until her death from a heart seizure on November 21, 1982. The couple never had children.
After Lee Patrick's death it was discovered that she was ten years older than she had ever revealed.